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Ethics declarations Ethics approval and consent to participate As this study is a systematic review and meta-analysis of previously published data, ethical approval was not required by the authors institutional review board

Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome

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Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity, and Metabolism, vol